Dear Colleagues,

Redox-regulated signaling pathways are emerging as key players in modulating multiple cellular functions that control tissue and organ pathophysiology. Cardiovascular and metabolic diseases, cancer, inflammatory, autoimmune, and chronic degenerative diseases all appear to share an unbalanced redox homeostasis due to increased reacting oxygen species (ROS) production or decreased body antioxidant response. While the physiological levels of ROS act as signaling molecules that maintain healthy body functions, high levels of ROS aberrantly affect organ and system homeostasis, ultimately prompting disease onset and progression.

Increased ROS generation and oxidative stress are also recognized as principal mechanisms of drug- and compound-associated toxicity. For instance, while low concentrations of exogenous antioxidants may positively impact cell function by maintaining redox homeostasis or preventing its imbalance, high concentrations of these compounds can instead promote oxidative stress. Based on the body's redox environment and their concentration, many exogenous compounds/drugs can negatively impact the body's redox-regulating machinery, promoting cell and tissue damage by oxidative stress. In this light, understanding the intricate machinery underpinning the body's redox homeostasis control may pave the way for better preventive and therapeutic approaches against diseases and compounds/drug-associated threats.

This Special Issue invites original research articles that explore and enhance our understanding of redox signaling in various pathological conditions, including cancer, cardiovascular and metabolic diseases, inflammatory, autoimmune, and chronic degenerative diseases. The issue aims to highlight potential redox-associated therapeutic approaches that could be useful in preventing or counteracting these conditions. Research articles that investigate and report new aspects of redox-regulated signaling phenomena triggered by the interaction of compounds/drugs with the cell/organ/tissue/body redox-regulatory apparatus are also particularly welcome. We also appreciate the submission of review articles that critically assess and discuss the current state of the art concerning the highlighted topics.

Dr. Gianfranco Pintus
Guest Editor

Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.