Submission Deadline: 30 September 2024 (Status: Open)
Special Issue Editor(s)
Sarmistha Saha
Email
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Website
Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura, Uttar Pradesh, India
Interests:
inflammation; oxidative stress; phytochemicals; nanomaterials; drug delivery
Special Issue Information
Dear Colleagues,
Inflammation and redox disturbances play a crucial role in many pathophysiological conditions, such as Alzheimer’s, cancer, and atherosclerosis. Extensive research has been conducted on the crosstalk of essential transcription factors and epigenetic signatures in inflammation and redox mechanisms, which showed the interference of NRF2, NF-κB, and AP1 signaling pathways. The inducible transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is responsible for the expression of nearly 250 genes encoding for a series of enzymes engaged in glutathione and thioredoxin-mediated pathways, inflammatory pathways, autophagy, and many others. However, some controversies still exist in the role of NRF2 axis activation in either the inhibition or the induction of the inflammatory response in pathological crystals-related diseases. Therefore, exploring whether the sustained NRF2 activation could lead to other complications is also necessary. Considering that current treatment approaches for redox imbalances and inflammation-mediated disorders are limited, it is essential to focus on potential alternatives. This Special Issue aims to gather the recent state-of-the-art research on the interplay of NRF2 with different inflammation mechanisms. Possible topics include but are not limited to the role of NRF2 in disease model systems, interactions of NRF2 with MAPK or JAK/STAT networks, and new information from preclinical to clinical implications of NRF2-based therapeutics.
Sarmistha Saha
Guest Editor
Keywords
inflammation; antioxidants; Nrf2
Manuscript Submission Information
Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.
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