Dear Colleagues,

Neurotoxicity has become a significant health issue today, and it is mainly caused by environmental problems, poor eating habits, personal addictions, and low physical activity.

Neurotoxicity refers to pathologies that develop due to agents that affect the central and peripheral nervous system tissues. In this context, neurons, astrocytes, oligodendrocytes, and microglial cells are damaged in the brain. The most common factors affecting neurons are hypoxia and external or internal chemical injurious agents. Neurons are the most energy-consuming cells in the body. In hypoxia, cellular energy metabolism is affected, leading to a decrease in energy production. Supporting glial cells try to reduce the energy deficit in neurons through monocarboxylate transporters. Apart from the decrease in the blood flow to the brain, many chemical toxic agents are essential in neurotoxicity by crossing the blood-brain and blood-CSF barrier.

Overeating or excessive carbohydrate consumption also causes damage to neurons. Peripheral neuropathy is the most common chronic complication of diabetes. Also, general nutritional defects caused by vitamin, mineral, and protein deficiencies occurring due to poor eating habits lead to neurotoxicity.

In addition, personal addiction to alcohol, cigarettes, some addictive agents and some drugs also creates neurotoxic effects. Alcohol disrupts energy metabolism and vitamin use, cigarettes cause cellular damage due to the carcinogenic and toxic substances, and addictive agents and drugs disrupt neurotransmitter activity.

Therefore, exposure to substances that cause neurotoxicity is inevitable today. Studies on this subject will undoubtedly make significant contributions to neurological well-being. In this context, this special issue of neurotoxicity will make an important contribution to this field.

Prof. Mevlut Sait Keles
Guest Editor

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