Special Issues

Pharmacological Advances in Herbal Medicine and Natural Product Drug Discovery
Editor: Yadu Nandan Dey

Submission Deadline: 30 November 2023 (Status: Closed)


Special Issue Editor


Dr. Yadu Nandan Dey      Email   |   Website
Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, West Bengal, India
Interests: toxicity studies; preclinical studies; herbal drug development; ethnopharmacology; diabetes; urolithiasis; arthritis; inflammation; network pharmacology; molecular docking


Special Issue Information

Dear Colleagues,

Although there has been marked advancement of modern medicine, traditional herbal medicine is still the primary form of treating diseases in the majority of people in developing countries and even among those where western medicine is available. In recent years, there has been a tremendous increase in the world population who uses complementary or alternative medicine. The increase in the knowledge of metabolic processes has led to molecular studies elucidating the molecular mechanisms of herbal medicines and pharmacological networks to predict the synergistic effect of the multiple components of herbal drugs. Interestingly, the demands of the market for medicinal herbs are likely to remain high because many natural products or phytoconstituents in medicinal plants cannot yet be synthesized. Most herbal preparations are free from adverse effects. Herbal medicine provides a rational treatment of many disease or conditions which are difficult to treat or incurable in other types of treatment, such as allopathic medicine.

This topic of the Special Issue is focused on gathering original research on herbal drugs and natural products, including phytochemical studies, in silico network pharmacology and molecular docking studies, in vitro assays, including the use of cell lines, and in vivo preclinical toxicological and pharmacological studies, along with molecular studies of plant extracts and natural products. Reviews on herbal medicine and natural product research are also within the scope of this special issue.

Yadu Nandan Dey
Guest Editor


Keywords

natural product; medicinal plants; herbal drug development; ethnopharmacology; preclinical studies; toxicity studies; in silico studies; network pharmacology; in vitro studies


Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.


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  • Article
    Hamid Kabdy, Abdelmounaim Baslam, Anass Belbachir, Stefania Garzoli, Abderrahman Chait
    Journal of Biological Regulators and Homeostatic Agents. 2024, 38(3): 2105-2114. https://doi.org/10.23812/j.biol.regul.homeost.agents.20243803.165
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    Background: Cannabis sativa L. is an annual plant from the Cannabaceae family. In Morocco, it has a long-standing traditional use. This study aimed to perform a chemical analysis of the Cannabis sativa essential oil (CSEO) and assess its acute toxicity, antioxidant properties, and analgesic effects.

    Method: Chemical analysis was conducted on the essential oil extracted from Cannabis sativa using gas chromatography-mass spectrometry (GC/MS) to identify its components. Subsequently, we carried out in vitro assessments of antioxidant activities using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging method (DPPH), the iron reduction method, and the β-carotene assay. Concurrently, we conducted investigations into the antinociceptive activity using three distinct animal models: the writhing test, the formalin test, and the hot plate test, as well as the acute toxicity by determining the lethal dose 50 (LD50).

    Results: The GC/MS analysis of the CSEO allowed the identification of its major compounds, namely (E)-caryophyllene α-humulene and caryophyllene oxide. The antioxidant activity was also significant due to its ability to scavenge DPPH (IC50 = 1.16 ± 0.08 mg/mL) and reduce iron potency (IC50 = 1.49 ± 0.46 mg/mL) and IC50 = 1.8 ± 0.2 mg/mL for β-carotene/linoleic acid assay. Acute toxicity (LD50) was evaluated at 42.46 mg/kg, indicating a relatively high tolerance, while a significant analgesic effect was observed, persisting for 120 minutes.

    Conclusions: The study provides promising results for the essential oil of the Moroccan variety of Cannabis sativa (C. sativa), showing its potential therapeutic properties as an antioxidant, and analgesic agent.