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PIO CONTI Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy

Press release:

University of Chieti-Pescara, Italy

Monday, May 8, 2017

Prof. Pio Conti is the co-author of an important research published in the prestigious US newspaper PNAS

Prof. Pio Conti, immunologist, is among the authors of a research entitled "SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors" published in the important journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE UNITED STATE OF AMERICA (PNAS), official organ of the Academy of Sciences of the USA and with a very high international diffusion.

The publication was produced in collaboration with the TUFTS University of Boston, where Prof. Pio Conti has been working and teaching for several decades with the role of "Affiliated Professor".

The work was presented for publication by Prof. Susan Leeman, of the University of Boston, an expert and well-known researcher (already nominated for the Nobel Prize) who has discovered and isolated some neurotransmitters, including the "Substance P ".

The article, with a high scientific impact, highlights, for the first time, the cooperation between a brain neurotransmitter (Sostaza P) and an inflammatory cytokine (IL-33), which together and synergistically contribute to the stimulation of a inflammatory cell (the mast cell), involved in allergy, tumors and neuronal diseases to produce another highly inflammatory protein (TNF = Tumor Necrosis Factor).

The interaction between these two proteins (Substance P and IL-33) increases the production of TNF by about a thousand times, an absolutely unexpected effect.

The experiments were performed using mast cells from stem mother cells. Surprisingly, these inflammatory biological effects were partially inhibited by some natural anti-oxidants of the flavonoid family, demonstrating once again how many plants can help in inflammatory diseases.

Since substance P is produced by brain cells and IL-33 by immune cells, the article suggests how important communication is between the brain and the immune system.

The results of the research, which highlights the relationships between the different inflammatory receptors, have aroused considerable interest in the international scientific community, as this is a basic bio-medical topic extensible to all inflammatory diseases including rheumatoid arthritis, asthma, atherosclerosis, psoriasis, allergy, tumors, Alzheimer's, and many psychiatric diseases.

The study was carried out exclusively with funds from TUFTS University in Boston Ma. (USA). For many years, Prof. Conti has managed to successfully carry out a fruitful collaboration with the US laboratory of TUFTS, the "Molecular Immunopharmacology and Drug Discovery", thus qualifying our "G. D'Annunzio "of Chieti.

source: unich.it

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The liaison between Prof. Pio Conti and TUFTS University in Boston, USA, has produced important publications, including:

Pio Conti articles