JBRHA Special Issue n. 2, 2021, MS L20201109 (AHEAD OF PRINT)



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Effects of meropenem on oxidative stress and inflammation in mice with septic liver injury

Y. Sui1, SH. Feng2, YH. Nie3, QY. Li4, HM. Sun5 and XY. Bai1

Author information

1Department of Pharmacy, Qingdao Hospital of Traditional Chinese Medicine, Qingdao Hiser Hospital, Qingdao, China;
2Department of Spine Surgery, Qingdao Hospital of Traditional Chinese Medicine, Qingdao Hiser Hospital, Qingdao, China;
3Department of Clinical Laboratory, Qingdao Central Hospital, Qingdao University, China;
4Department of Radiology, Zhangqiu District People’s Hospital, Jinan, China;
5Hospital Infection-Control Department, Zhangqiu District People’s Hospital, Jinan, China

Abstract

The aim of this study is to observe the anti-oxidative stress protection and the inhibitory effect of meropenem injection on acute liver injury in septic rats. Fifty-four healthy Wistar rats were randomly divided into control group, sepsis group and drug treatment group. Sepsis models were made by cecal ligation and perforation. At 8, 16, and 24 h after the establishment of the model, the oxidative stress response of the liver, the changes of cytoinflammatory factors and the pathological changes of hepatocytes in sepsis liver injury were detected in each group. The results, compared with the control group at 8, 16 hours after cecal ligation and perforation, the oxidative stress indexes of the sepsis group and meropenem group, did not change significantly, while CRP did increase significantly (P<0.05); After 16 hours, compared with the sepsis group, MDA and TNF-α decreased, and IL-10 began to increase in the meropenem group; The meropenem group had lower serum ALT and AST ( P<0.05), liver GSH, SOD content was significantly increased (P<0.05), MDA content was reduced (P<0.05), serum CRP, TNF-α concentration was significantly reduced (P<0.01), and IL-10 significantly increased compared with the sepsis group after 24 h (P<0.01). Immunohistochemical analysis showed that meropenem can effectively reduce the oxidative stress in the liver of septic rats (P<0.05, P<0.01). Early application of meropenem injection in sepsis can resist oxidative stress response, stabilize liver cell membrane permeability, inhibit inflammatory factors, and play a certain protective effect on acute liver injury caused by sepsis.

Keywords:

meropenem, sepsis, liver injury, oxidative stress, inflammatory cytokines

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