JBRHA Special Issue n. 2, 2021, MS J20200916 (AHEAD OF PRINT)



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Effect of sevoflurane combined with propofol anesthesia on brain-derived neurotrophic factor, s100b protein and cognitive function in elderly patients undergoing electro-prostatectomy

GM. Li1, J.G. Li2, M. Liu1 and B. You1

Author information

1Department of Urology, Tai’an Traditional Chinese Medicine Hospital, Tai’an, Shandong Province, China;
2Anesthesiology Department, Tai’an Traditional Chinese Medicine Hospital, Tai’an, Shandong Province, China

Abstract

The purpose of the study was to investigate the effect of sevoflurane combined with propofol anesthesia on the brain-derived neurotrophic factor (BDNF), S100B protein and cognitive function in elderly patients undergoing electro-prostatectomy. One hundred elderly patients undergoing electro-prostatectomy in our hospital from January 2019 to March 2020 were randomly divided into experimental group (n=50) and control group (n=50). Among them, the control group was treated with propofol anesthesia, while the experimental group was treated with sevoflurane on the basis of the control group. BDNF levels, S100 protein levels and Montreal cognitive assessment (MoCA) scores were compared between the two groups at 6 h, 24 h and 72 h before and after operation. Before operation, there were no significant differences in the three indexes between the two groups (P >0.05). At 6 h and 24 h after operation, the BDNF levels and MoCA scores in the two groups were lower than those before operation and the decrease in the experimental group was less than that in the control group (All P <0.05). The S100B protein levels were higher than those before operation, and the increase in the experimental group was less than that in the control group (All P <0.05). BDNF levels, S100B protein levels and MoCA scores in the two groups all recovered to the preoperative levels (P >0.05). Decreased cognitive function of anesthetized patients is associated with the decreased BDNF and increased S100B protein. Therefore, sevoflurane combined with propofol anesthesia can increase BDNF and decrease S100B protein, thus reducing the effect of propofol anesthesia on elderly patients undergoing electro-prostatectomy.

Keywords:

sevoflurane, propofol, electro-prostatectomy, brain-derived neurotrophic factor (BDNF), S100B protein, cognitive function

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