J Biol Regul Homeost Agents. May-Jun 2021; 35(3):865-880. doi: 10.23812/20-592-A.


Phageome-based vaccination and human innate immune modulation could be a useful strategy to control human Coronavirus infections

Abaidullah M1, Peng S1, Kamran M2, Song X1, Ali Sher A3, Chen Y1, Rehman A4, Lin L1, Jia R5, Yin Z1.

Author information

1  Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
2  Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, Australia.
3  College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
4  College of Veterinary and Animal Sciences, Jhang, Pakistan.
5  Key laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.


Human Coronavirus (CoV) infections, including SARS-COV, MERS-COV, and SARS-CoV-2, usually cause fatal lower and upper respiratory tract infections due to exacerbated expression of pro-inflammatory cytokines and chemokines. We aim to summarize different aspects, such as CoV immune evasion mechanisms and host innate immune response to these infections, and their role in pathogenesis. We have also elaborated the up-to-date findings on different vaccine development strategies and progress against CoVs in both humans and non-human models. Most importantly, we have described the Phageome-human immune interaction, its therapeutic usage as anti-viral, anti-inflammatory agent, and implications for multiple vaccine development systems. The data suggest that endogenous phages might play a vital role in eliminating the infection and regulating the body’s immune system. Considering the innate-immune-induced pathogenesis against CoVs and the therapeutic aptitude of phageome, we propose that the prophylactic administration of phages and phage-based vaccines could be a useful strategy to control the emerging CoV infections.


anti-inflammatory, anti-viral, chemokines, cytokines, pathogenesis

Publication type

  • Review

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