J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1 Suppl. 2):33-38. doi: 10.23812/21-1supp2-7.

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Risk factors for recurrent acute otitis media: a real-life clinical experience

Ciprandi G1, Ameli F2, Asmanov A3, Passali FM4, Tosca MA5.

Author information

1 Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
2 Otorhinolaryngology Unit, Casa di Cura Villa Montallegro Health, Genoa, Italy.
3 Pirogov Russian National Research Medical University, Moskow, Russia.
4 Department of Clinical Sciences and Translational Medicine, University of Tor Vergata, Rome, Italy.
5 Allergy Center, Istituto G. Gaslini, Genoa, Italy.


Acute otitis media (AOM) is the most common bacterial infection in children. Some children with AOM tend to be otitis-prone, such as frequent recurrence of AOM (RAOM). Possible RAOM risk factors are widely debated. The current study was performed in a real-life setting, such as an otorhinolaryngologic (ORL) clinic, to identify predictive factors, including clinical data and endoscopic findings, for RAOM in children. In this study, 1,002 children (550 males, 452 females, mean age 5.77 + 1.84 years) complaining of upper airway symptoms were consecutively visited. Detailed clinical history and nasal endoscopy were performed. Throughout the ORL visit, it was possible to define some factors involved in the recurrence of AOM, including female gender, artificial feeding, tonsillar and adenoid hypertrophy. Adenoid and tonsillar hypertrophy, female gender, and artificial are factors significantly associated with RAOM. Therefore, reducing adenoid and tonsil size, also using topical corticosteroids or glycyrrhizin, could be a reasonable strategy to potentially reduce adenoid and tonsil size. The current study suggests that also in a primary care setting, it is possible to achieve meaningful information that is relevant in clinical practice.


children, predictive factors, real-life, recurrent acute otitis media, tonsils

Publication type

  • Clinical Study

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