J Biol Regul Homeost Agents. 2021 Jan-Feb;35(1 Suppl. 2):21-25. doi: 10.23812/21-1supp2-5.

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Can Pseudomonas aeruginosa growth be modulated by natural compounds?

Passali D1, Ionescu A2, Brambilla E2, Bellussi LM3, Ciprandi G4, Mattina R2, Passali GC5,6.

Author information

1 International Federation ORL Societies (IFOS) Executive Board members, Rome, Italy.
2 Department of biomedical, surgical,and dental sciences, University of Milan, Milan, Italy.
3 International Federation ORL Societies (IFOS), Rome, Italy.
4 Consultant allergist, Casa di Cura Villa Montallegro, Genoa, Italy.
5 UOC di Otorinolaringoiatria, Dipartimento Scienze dell’Invecchiamento,Neurologiche, Ortopediche e della testa collo. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
6 Institute of Otolaryngology, Università Cattolica del Sacro Cuore, Policlinico Agostino Gemelli, Rome, Italy.


Pseudomonas aeruginosa is an opportunistic human pathogen that frequently induces antibiotic resistance, as it mainly tends to form biofilms. Iron chelation may be an intriguing strategy to contrast bacterial growth. Lactoferrin is a natural compound able to chelate iron. A new multi-component medical device also contains lactoferrin. This study analyzed this compound investigating the in vitro capacity to inhibit Pseudomonas aeruginosa growth. In conclusion, this study demonstrated that a multicomponent medical device (Saflovir), also containing lactoferrin, could inhibit the in vitro growth of P. aeruginosa. This activity could be positively used in the prevention of respiratory nasal infections.


Pseudomonas aeruginosa, biofilms, lactoferrin

Publication type

  • Clinical Study

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