J Biol Regul Homeost Agents. 2020 Jan-Feb;34(1):93-100. doi: 10.23812/18-403-A.


Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition.

Wang J1, Yao X2, Wu DL3, Jin Y4.

Author information

1 Department of Gynecology, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
2 Department of Anesthesiology, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
3 Department of Encephalopathy, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
4 Department of Gynecology, Jilin Academy of Traditional Chinese Medicine, Changchun, Jilin, China.

FULL ARTICLE 

Abstract

Endometriosis is a gynecological health problem for women of reproductive stage. Kallikrein 4 is a proliferative factor and has important roles in cancer development and progression. To explore the role of Kallikrein 4 in endometriosis, we detected the expression of Kallikrein 4 in ectopic and normal control endometriosis tissues. Moreover, the underlying influence of Kallikrein 4 on migration and invasion of endometrial stromal cells was investigated. Furthermore, the correlations between this gene and E-cadherin and N-cadherin were also evaluated. The results demonstrated that the expression level of Kallikrein 4 in endometrial tissues was significantly increased compared to normal endometrial tissues, and over-expression of Kallikrein 4 up-regulated expression of N-cadherin but down-regulated E-cadherin in endometrial stromal cells. The ability of migration and invasion of endometrial stromal cells in vitro was increased by up-regulating Kallikrein 4 expression, suggesting that Kallikrein 4 might be involved in the development of ovarian endometriosis.

KEYWORDS:

Kallikrein 4, endometriosis, invasion, migration

Publication type

  • Journal Article

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