J Biol Regul Homeost Agents. 2019 Nov-Dec;33(6):1663-1667. doi: 10.23812/19-Edit_Theoharides.
Factors adversely influencing neurodevelopment.
- 1 Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston. MA, USA.
- 2 Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.
- 3 Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA.
- 4 Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA.
- 5 Graduate Program in Education, Lesley University, Cambridge, MA, USA.
- 6 Casa di Cura Villa San Marco, Ascoli Piceno, Italy.
Neurodevelopment has been studied extensively, especially in respect to abuse, anoxia, nutritional status
and prematurity/low birth weight. However, less attention has been paid to innate and environmental
factors, as well as to inflammatory conditions that may adversely affect neurodevelopment and learning
in children. These include heavy metals, herbicides and polyvinyl chlorides (PVCs), mycotoxins, viral
infections and Lyme disease-associated pathogens, as well as number of conditions such as chronic
inflammatory response syndrome (CIRS) and Mast cell activation syndrome (MCAS). Early recognition
of factors/conditions that could interfere with neurodevelopment is critical. Corrective actions, including
the use of some unique natural flavonoids, could have lasting beneficial results.
autism, brain, flavonoids, inflammation, learning, mast cells, neurodevelopment