J Biol Regul Homeost Agents. 2019 Oct 7;33(5). doi: 10.23812/19-136-A. [Epub ahead of print]
Molecular evaluation of tissue proteins in vivo during controlled orthodontic movement.
- 1 Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, School of Dentistry, University of Messina, Italy.
- 2 School of Dentistry, Department of Orthodontics, Vita-Salute San Raffaele University, Milan, Italy.
- 3 Unit of Dentistry, Division of Orthodontics, Research area in Dentofacial Orthopedics and Orthodontics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
- 4 Private practice Milano and Bologna Italy.
Orthodontic tooth movement determines a biological response of all the tissues surrounding the teeth to which force is applied. The aim of this study is to evaluate which ideal orthodontic force, at the biological level, arouses an acute inflammatory response on periodontal tissues, and the duration of the force in order to establish an ideal experimental model of dental movement. The periodontal ligament and the alveolar bone change abruptly due to the biochemical adaptive response, resulting in a re-organization of the intracellular and the extracellular matrix. There is a modification of the local vascularization which stimulates a cascade production, synthesis and the release of arachidonic acid, metabolites, proteins, such as cytokines, and growth factors. Every dentist can control and should know the above-mentioned mechanism. Moreover, the production of proteins by modulating the direction and the intensity of the force can be changed but, above all, the duration.
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molecular evaluation, orthodontic, tooth movements
- Journal Article