JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS Vol. 33, no. 3, 883-887 (2019)


Association of GPIa C807T polymorphism with unexplained female infertility and IVF implantation failure.

Kydonopoulou K1, Rousso D2, Ilonidis G1, Mandala E1.

Author information

1 Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.
2 Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.

Abstract

Glycoprotein Ia (GPIa), also known as integrin alpha 2 (ITGA2), together with GPIIa (ITGB1), form the heterodimer integrin α2β1. This complex is a major collagen receptor on the membrane of platelets, which is involved in thrombus formation through platelet adhesion and activation.

KEYWORDS:

C807T polymorphism, GPIa, ITGA2, IVF, implantation, thrombophilia, unexplained infertility

Publication type

  • Letter

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