J Biol Regul Homeost Agents. 2019 Jan-Feb;33(1):309-313.

Application of stem cells in oral science: a literature review.

Lucchese A1,2, Botta R3, Lucchese C1,2,4, Croce S1,2, Marcolina M1,2, Manuelli M1,2.

Author information

1 Department of Orthodontics, Vita Salute San Raffaele University, Milan, Italy.
2 Unit of Dentistry, Division of Orthodontics, Research area in Dentofacial Orthopedics and Orthodontics, IRCCS San Raffaele, Scientific Institute, Milan, Italy.
3 Department of oral Surgery, Vita Salute San Raffaele University, Milan, Italy.
4 Private Practice, Bologna, Italy.


The objective of this work was to provide a review of the literature on studies of stem cells and their potential applications in dental practice. Research included every article published between 2000 and 2018 in PubMed PMC, Scopus, Cochrane Trial Library, and Web of Science databases featuring the keywords: regenerative dentistry, stem cells, tissue engineering. Papers that did not directly address the subject were excluded. Emphasis was given to scientific studies that showed possibilities of stem cell therapy in the oral and maxillofacial region. The methodological quality of selected papers was scored using the “Swedish Council on Technology Assessment in Health Care Criteria for Grading Assessed Studies” (SBU) method. Two review authors independently assessed eligibility, extracted data and verified the quality of the studies.

Publication type

Publication type

  • Letter

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