J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6):1345-1347.


Stress, inflammation and natural treatments.

Theoharides TC1,2,3,4, Kavalioti M5.

Author information

1 Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.
2 Department of Internal Medicine, Tufts University School of Medicine, Boston, MA, USA.
3 Department of Psychiatry, Tufts University School of Medicine, Boston, MA, USA.
4 Sackler School of Graduate Biomedicalm, Sciences, Tufts University School of Medicine, Boston, MA, USA.
5 Department of Biomedical Sciences, University of Greenwich, UK – *present address: BiomedAdvice, LLC, Boston, MA, USA.

Abstract

Stress and inflammation have become the curses of our times and are the main pathogenetic factors in multiple diseases that are often comorbid and include allergies and asthma, eczema and psoriasis, fibromyalgia syndrome, mast cell activation syndrome, irritable bowel syndrome, myalgic encephalomyelitis/chronic fatigue syndrome and autism spectrum disorder (ASD). Unfortunately, there are no effective drugs. Cross-talk between mast cells and microglia in the hypothalamus and amygdala could explain stress-induced inflammation. We recently showed that the “alarmin” IL-33 could play a major role through its synergistic action with the neuropeptide substance P to stimulate human mast cell secretion of the pro-inflammatory molecules IL-1β, TNF and VEGF. A new formulation using pure luteolin with Ashwagandha has now been developed and could be of significant benefit to patients suffering from these diseases.

Publication type

  • Editorial

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