J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):211-219. Epub 2018 Jul 31.

Patient-reported quality of life after endoscopic surgery for pituitary lesions: a meta-analysis.

Wang CH1, Zhu N2.

Author information

1 Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
2 National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China.


Patient-reported outcomes are now considered as an important part of overall outcome assessment of a surgical intervention. The objective of the current study was to evaluate the patient-reported quality of life (QoL) of the subjects of endoscopic pituitary surgery. A literature search was carried out in several electronic databases and study selection was based on pre-determined eligibility criteria. Meta-analyses of standardized mean difference (SMD) were conducted to observe significance of difference between preoperative and postoperative scores of important tools. Sixteen studies were included [931 patients; 51.16 years (95% CI 49.13, 53.19) age; 48.41 % (43.74, 53.08) males]. Generally, there was no significant differences between postoperative and preoperative health-related QoL after postoperative month 1 or after fourth postoperative month. QoL after endoscopic pituitary surgery remains unchanged predominantly but may deteriorate in regard to physical role and sinonasal outcome transiently.

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