J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):1061-1065.


IL-33 mediates allergy through mast cell activation: Potential inhibitory effect of certain cytokines.

Tettamanti L1, Kritas SK2, Gallenga CE3, D’Ovidio C4, Mastrangelo F5, Ronconi G6, Caraffa A7, Toniato E8, Pio Conti 9.

Author information

1 Department of Medical and Morphological Science, University of Insubria, Varese, Italy.
2 Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece.
3 Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Italy.
4 Section of Legal Medicine, Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Italy.
5 Department of Medical Science and Biotechnology, University of Foggia, Foggia, Italy.
6 UOS Clinica dei Pazienti del Territorio, Policlinico Gemelli, Rome, Italy.
7 School of Pharmacy, University of Camerino, Camerino, Italy.
8 Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy.
9 Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy.

 

FULL ARTICLE

Abstract

Mast cells (MCs) are hematopoietic immune cells commonly found in adjacent to blood vessels in the lamina propria of airway mucosa. They are important in allergic reactions since the cross-linking of their surface high affinity receptor FceRI induces activation of these cells, and provokes the synthesis, degranulation and release of inflammatory mediators including arachidonic acid-derived eicosanoids (de novo synthesized), stored enzyme mediators, and inflammatory TH1 and TH2 cytokines, and chemokines. Interleukin (IL)-33 participates in innate and adaptive immunity and inflammation and, acting on CD34+ cells, causes MC differentiation and maturation. IL-33 is generated by activated immune cells, and activates MCs which degranulate and release pro-inflammatory mediators. IL-33 is very important in mediating allergic inflammation and can be induced by IL-1 beta. It is also called “alarmin” and is an inflammatory cytokine IL-1 family member, expressed from mocytes and MCs, which binds its receptor ST2, provoking its release after cell damage. MC-derived allergic compounds in response to IL-33 is critical to innate type 2 immunity. IL-37 is expressed by immune and non-immune cells after pro-inflammatory stimulus. IL-37, an anti-inflammatory cytokine, binds IL-18Ra and suppresses pro-inflammatory IL-1 beta released by activated immune cells such as macrophages. Here, we hypothesize that pro-inflammatory IL-1 family member cytokines released by activated MCs, mediating inflammatory allergic phenomenon, can be suppressed by IL-37.

Publication type

Publication type

  • Editorial

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