J Biol Regul Homeost Agents. 2018 May-Jun;32(3):613-618.


Comparison of gefitinib and platinum-based chemotherapy and only platinum-based chemotherapy to treat lung adenocarcinoma.

Yang L1, Fan JH2, Liu LL2, Su Y1, Lu D1, Huang JY1, Zhang H1, Li Y1, Huo HD1, Liu GT3.

Author information

1 Central Sterile Supply Department, Affiliated HongQi Hospital of Mudanjiang Medical University, Mudanjiang City, Heilongjiang Province, China.
2 Department of Pharmacy, Affiliated HongQi Hospital of MuDanJiang Medical University, Mudanjiang City, Heilongjiang Province, China.
3 Department of Thoracic Surgery, Affiliated HongQi Hospital of Mudanjiang Medical University, Mudanjiang City, Heilongjiang Province, China.

Abstract

To study the curative effects and safety for patients who adopt both gefitinib and platinum-based chemotherapy or only platinum-based chemotherapy in the treatment of lung adenocarcinoma, 80 EGFR mutation-positive lung adenocarcinoma patients in stage IIIB/IV were divided into two groups. Half of them received both gefitinib and standard chemotherapy (group A), and the others (group B) received only standard chemotherapy. Overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS) and the related toxicities of both groups were recorded in order to take certain nursing measures for a variety of toxicities. Next, statistical methods were used to analyze the curative effects and safety of the two treatments. The results showed that ORR, DCR and median progression-free (mPFS) survival of the two groups of patients showed no statistical difference (P >0.05). However, group A (18.56 months) had a longer median overall survival (mOS) than group B (14.87 months), which was of statistical significance (P less than 0.05). Nausea and loss of appetite were common mild adverse reactions, and anemia and leukocytopenia were moderate common adverse reactions. The difference between these two groups of patients regarding adverse reactions was not statistically significant (P>0.05). In conclusion, the two treatments have similar safety, but lung adenocarcinoma patients with drug resistance during stage IIIB/IV after using first-line gefitinib therapy have lower survival benefits than patients who take both gefitinib and platinum-based chemotherapy.

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