Methylmercury-l-Cysteine targeting L-type amino acid transporter conjugate cytotoxicity on C6 glioma cells.
Z.Y. Wei 1, M.M. Feng 2, B. Yang 2, Z.Y. Yan 2, B.Q. Wang 2, X.Y. Bu 2
1 Department of Neurosurgery, The No.371 Central Hospital of the People’s Liberation Army, Xinxiang, China
2 Department of Neurosurgery, Henan Provincial People’s Hospital, The People’s Hospital of Zhengzhou University, The People’s Hospital of Henan University, Zhengzhou, China
Glioma is the most common primary tumor in the brain, accounting for about 40~50% of intracranial primary tumors. Most chemotherapeutic drugs have difficulty in penetrating the blood-brain barrier, and their clinical applications are greatly limited. We evaluated the effects of methylmercury-L-cysteine (MeHg-L-cys) and methylmercury chloride (MMC) on apoptosis of C6 glioma cells. L-type amino acid transporter (LAT1) was used to investigate the targeted transport function and cytotoxicity of MeHg- L-cys in glioma. MeHg-L-cys enhanced the ability of targeting glioma cells and reduced the adverse reactions to normal brain tissues. Therefore, it is significantly important to develop new anti-glioma drugs targeting the blood-brain barrier.