JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS Vol. 32, no. 4, 983-988 (2018)


Emerging from gastroesophageal reflux (EMERGE): an Italian survey – II the viewpoint of the patient.

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M. BIANCHETTI 1, S. PERALTA 2, R. NICITA 3, S.E. ARAGONA 4, G. CIPRANDI 4 and the EMERGE STUDY GROUP*

1 Gastroenterologia, Humanitas Mater Domini, Castellanza (VA), Italy

2 Endoscopia Digestiva, Policlinico P. Giaccone, Università di Palermo, Palermo, Italy

3 Gastroenterologia, ASP 5, Reggio Calabria, Italy

4 Center of Regenerative Medicine, Humanitas Mater Domini, Castellanza (VA), Italy

5 Ospedale Policlinico San Martino, Genoa, Italy

*EMERGE Study Group:  A. Arrigoni, D. Artuso, M. Astegiano, C. Azzinnari, E. Battaglia, C. Belcari, E. Bendia, P. Benedicenti, M. Bianchetti, G. Brandimarte, I. Buoncompagni, M. Cabras, S. Camilleri, G. Capece, S. Caronna, C. Cassieri, F. Castaldo, T. Catalano, C. Citarella, F. D’amore, G. D’alia, F. D’arpa, A. Dattola, N. De Bortoli, A. De Medici, S. Di Marzo, R. Di Mitri, A. Di Napoli, V. D’onofrio, L. Dughera, W. Elisei, G. Errico, L. Familiari, P. Familiari, R. Frasca, A. Frunzio, M. Gatti, S. Genova, S. Grosso, R. Gullotta, D.R. Iannuzziello, G. Indennitate, G. Leonardi, C. Luigiano, B. Macchiarella, T. Maisto, M.G. Mancino, A. Mancino, G. Manes, R. Marin, G.R. Mastinu, A. Moi, L.M. Montalbano, N. Monterosso, A. Morabito Loprete, L. Morlando, R. Nicita, C. Ogliari, N. Paiano Primaldo, G. Paliani, A.P. Palieri, D. Pardocchi, A. Pati, G. Pedretti, S. Peralta, A. Pisani, P. Plomaritis, A.C. Privitera, R. Pumpo, F. Quatraro, D. Raimondo, G. Rivellini, L. Rizzo Giovanni, M. Romano, R. Salerno, E. Savarino, G. Scarpulla, E. Sinagra, M. Soncini, G. Tammaro, C. Trovato, R.  Vassallo, M. Vinti, C.M.P. Virgilio

 

Gastroesophageal reflux disease (GERD) is a very common disease, as about a quarter of the Western population has GERD symptoms at least weekly and GERD is the most frequent reason for outpatient
gastroenterology consultation. GERD treatment is based on proton pump inhibitor (PPI) use, but PPI may be ineffective in some patients and potentially unsafe if administered for very long time. A new medical compound (Marial®) has been introduced on the Italian market. This product contains magnesium alginate and a phytopolymer: it may be able to repair ulcer/erosion, protect mucosal tissue, and contrast acid contents. The current survey was conducted on a large group of GERD patients visited at 56 Italian gastroenterological offices. Patients were treated with PPI alone, PPI plus add-on, or Marial® for 4 weeks: the choice was decided by each gastroenterologist on the basis of the best practice criterion. A reflux symptoms index (RSI) questionnaire was used to weekly assess the clinical features. Marial® and PPI plus add-on significantly reduced RSI scores, from the second week. Noteworthy, Marial® was more effective than PPI plus add-on. In conclusion, the current survey demonstrated that patients with GERD perceived a significant improvement of GERD symptoms measured by the RSI questionnaire. Marial® was as effective as PPI plus add-on.

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