Submission Deadline: 30 November 2023 (Status: Closed)
Special Issue Editor
Dr. Narasaiah Kolliputi Email | Website
Department of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
Interests: oxidative stress; cadmium; apoptosis; inflammation
Special Issue Information
Cadmium is a toxic heavy metal for humans. Apart of industrial workers, the most common exposure to cadmium is cigarette smoking. Smoking exposes human lungs to cadmium where it begins to increase reactive oxygen species and cause inflammation. Due to its long half-life and extremely poor endocrine clearance, cadmium toxicity is essentially permanent. Common heavy metal therapies like chelators are ineffective at reducing cadmium toxicity. Moreover, cadmium hijacks proteins allow zinc to enter the cell. Thus, Zinc’s role in the immune system is greatly reduced as a result, and cadmium is able to prolong its toxic effects. Cadmium’s toxicity mechanism needs to be better understood so that effective therapeutic targets can be elucidated. Currently, the most prevalent evidence for a mechanism is programmed cell death (PCD). Multi-arm cell death complex is an emerging concept in PCD that is the simultaneous activation of well-known PCD pathways (pyroptosis, apoptosis, and necroptosis). Cadmium is known to activate PCD regulators, but the precise mechanism of this is still unknown. Lung cancer, osteoarthritis, COPD, neural inflammation, and other diseases continue to persist in patients that have a history of cigarette smoking.
cadmium; heavy metal toxicity; oxidative stress; free radicals; apoptosis; inflammation; lung inflammation; lung injury and cell signaling
Manuscript Submission Information
Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.
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