Dear Colleagues,

Nanoparticles have attracted scientific interest for drug delivery and diagnosis owing to their small size, high drug-loading capacity, large surface area, and surface functionalization/engineering with targeting moieties. They have revolutionized the field of medicine by enabling targeted delivery of drugs selectively to sites of interest while minimizing their off-target side effects.

This special issue explores the molecular mechanisms and pharmacological aspects of nanoparticles for targeted drug delivery and diagnosis, with a focus on cancer treatment. The issue will cover a range of topics, including design and synthesis of nanoparticles, their physicochemical properties, and their interactions with biological systems.

Contributions to this issue will provide insights about nanoparticles-based drug delivery mechanisms for cancer treatment, including particle size, shape, and surface chemistry role in determining their pharmacokinetics and biodistribution. Additionally, authors will discuss the current status of preclinical and clinical studies about nanoparticle-based drug delivery systems for cancer therapy.

Specific aspects of nanoparticle-based drug delivery in cancer diagnosis and treatment that will be included in this special issue include:

（1）The development of targeted nanoparticles that can selectively deliver drugs to cancer cells while sparing healthy cells.

（2）Nano-imaging agents for cancer diagnosis and monitoring of treatment response.

（3）The use of stimuli-responsive nanoparticles that can release drugs in response to specific triggers.

（4）The challenges and opportunities in translating nanoparticle-based drug delivery systems from preclinical studies to clinical trials.

This issue aims to deepen the knowledge about nanoparticle-based drug delivery molecular mechanisms and diagnosis in cancer treatment, to promote more effective and targeted therapies for cancer patients.

Muhammad Imran
Guest Editor

Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.