Dear Colleagues,

The free radical theory of aging supports that the continuous accumulation of unrepaired oxidative damage of macromolecules throughout the lifespan is the molecular basis of age-related physiological dysfunction. Oxidative accumulation rate dictates cellular/tissue senescence and, chronically, age-related physical and mental limitations, including its comorbidities. The positive effects of regular exercises rely on the hormesis principle: regular physiological challenges imposed by moderate exercises will demand gradually antioxidants progressive responses, housekeeping proteins and cytoprotective enzymes, which, altogether, improve the health conditions of those active subjects. Most of these positive adaptations occur via redox signaling pathways. Moreover, adequate nutrition, rich of antioxidants and micronutrient provisions, will assure proper redox balances that sustain sufficient redox signals for positive adaptations, without leading to exacerbated oxidative stress in active subjects. This SI will focus on the protective effects of regular exercises and/or nutrition (including supplementation) against age-related progressive oxidative stress conditions and its comorbidities. Original articles and reviews are welcome in the topic of gerontology, exercise and nutrition field.

Prof. Rafael Herling Lambertucci and Prof. Marcelo Paes de Barros
Guest Editors

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