Special Issues

The Role of Biological Regulators and Homeostatic Agents in Maintaining Health, Preventing Neurological and Hormonal Disorders
Editor: Ayman Elsayed Mohamed Elsahar

Submission Deadline: 31 January 2024 (Status: Open)

Special Issue Editor

Dr. Ayman Elsayed Mohamed Elsahar      Email   |   Website
1. Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2. School of Pharmacy, Newgiza University, Cairo, Egypt

Interests: neurological disorders; cancers; inflammatory diseases; gastric ulcers; parkinsonism; Huntington’s disease; multiple sclerosis; rheumatoid disorders

Special Issue Information

Dear Colleagues,

The role of biological regulators and homeostatic agents in maintaining health, preventing neurological and hormonal disorders is essential for the body to properly function. Biological regulators are molecules that act as messengers between cells, tissues, organs, and systems to maintain homeostasis. Homeostatic agents are substances that help to regulate body’s internal environment. They help to maintain a balanced state in the body by controlling various physiological processes, such as temperature, pH, osmotic pressure, and ion concentrations. Hormones are chemical messengers which control many functions in the body such as growth, metabolism, reproduction, and stress response. Neurotransmitters are chemicals released by neurons that transmit signals between nerve cells. Both, hormones and neurotransmitters, play an important role in regulating moods, emotions, behavior, and cognitive functions. These regulators control the production and release of hormones, neurotransmitters, and other physiological chemicals. When these regulators are imbalanced, they can lead to various neurological and hormonal disorders. For example, an imbalance in hormones can cause conditions such as depression, anxiety, and insomnia. Neurotransmitter imbalances can lead to conditions such as Parkinson’s disease, Alzheimer’s disease, and epilepsy. Biological regulators also control the body’s response to physical or emotional trauma stressors. Imbalances in these regulators can lead to conditions such as post-traumatic stress disorder (PTSD) or chronic fatigue syndrome (CFS). Understanding the role of biological regulators in neurological and hormonal disorders is crucial to better understand how to treat these different disorders effectively.

Ayman Elsayed Mohamed Elsahar
Guest Editor


biological regulation; homeostatic agents; hormones; neurotransmitters; metabolic control; signaling pathways

Manuscript Submission Information

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  • Article
    Bingjie Wu, Handan Hu, Lanxiao Liu, Peng Huang
    Journal of Biological Regulators and Homeostatic Agents. 2023, 37(9): 4623-4633. https://doi.org/10.23812/j.biol.regul.homeost.agents.20233709.452
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    Background: Obsessive-compulsive disorder (OCD) is a chronic, general, and usually disabling disorder. A family-based study has illustrated that the risk of OCD was related to genetics. This meta-analysis aims to assess the association between solute carrier family 1 member 1 polymorphisms (rs301430 and rs301434) and OCD susceptibility.

    Methods: The study comprehensively searched various databases without language restrictions, including the Cochrane Library database, PubMed, Embase, Web of Science, CNKI, CBM, VIP, and WanFang Data. The data were obtained before April 1, 2023, and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were utilized and pooled in the analysis using Stata 17.0 software. Sensitivity analysis was conducted to analyze the robustness and reliability of the results, and Egger's test was used to examine the publication bias. Trial Sequential Analysis (TSA) was performed by TSA Beta software to assess the required information size.

    Results: Based on the data derived from eight articles with 3932 participants (2147 OCD subjects and 1785 controls), the risk of OCD and its subtypes were observed to be associated with solute carrier family 1 member 1 (SLC1A1) rs301434 polymorphism (overall OCD: G vs. A: OR = 1.19, 95% CI = 1.06–1.34; GG vs. AA: OR = 2.18, 95% CI = 1.36–3.49; GG+GA vs. AA: OR = 1.21, 95% CI = 1.01–1.45; early-onset OCD: G vs. A: OR = 1.19, 95% CI = 1.04–1.37; GG vs. AA: OR = 1.79, 95% CI = 1.03–3.10; late-onset OCD: GG vs. AA: OR = 3.25, 95% CI = 1.36–7.78; GG vs. GA+AA: OR = 3.22, 95% CI = 1.34–7.76; OCD in Asians: G vs. A: OR = 1.20, 95% CI = 1.00–1.44; GG vs. AA: OR = 3.72, 95% CI = 1.61–8.56; GG vs. GA+AA: OR = 3.70, 95% CI = 1.61–8.51). Meanwhile, no association was found between OCD susceptibility and SLC1A1 rs301430 polymorphism.

    Conclusion: This meta-analysis demonstrates that the SLC1A1 rs310434 may be associated with OCD susceptibility, and more studies are needed to corroborate the conclusions.

    Systematic Review Registration: PROSPERO: CRD42023426696.