Special Issues

The Role of Biological Regulators and Homeostatic Agents in Maintaining Health, Preventing Neurological and Hormonal Disorders
Editor: Ayman Elsayed Mohamed Elsahar

Submission Deadline: 31 January 2024 (Status: Open)


Special Issue Editor


Dr. Ayman Elsayed Mohamed Elsahar      Email   |   Website
1. Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2. School of Pharmacy, Newgiza University, Cairo, Egypt

Interests: neurological disorders; cancers; inflammatory diseases; gastric ulcers; parkinsonism; Huntington’s disease; multiple sclerosis; rheumatoid disorders


Special Issue Information

Dear Colleagues,

The role of biological regulators and homeostatic agents in maintaining health, preventing neurological and hormonal disorders is essential for the body to properly function. Biological regulators are molecules that act as messengers between cells, tissues, organs, and systems to maintain homeostasis. Homeostatic agents are substances that help to regulate body’s internal environment. They help to maintain a balanced state in the body by controlling various physiological processes, such as temperature, pH, osmotic pressure, and ion concentrations. Hormones are chemical messengers which control many functions in the body such as growth, metabolism, reproduction, and stress response. Neurotransmitters are chemicals released by neurons that transmit signals between nerve cells. Both, hormones and neurotransmitters, play an important role in regulating moods, emotions, behavior, and cognitive functions. These regulators control the production and release of hormones, neurotransmitters, and other physiological chemicals. When these regulators are imbalanced, they can lead to various neurological and hormonal disorders. For example, an imbalance in hormones can cause conditions such as depression, anxiety, and insomnia. Neurotransmitter imbalances can lead to conditions such as Parkinson’s disease, Alzheimer’s disease, and epilepsy. Biological regulators also control the body’s response to physical or emotional trauma stressors. Imbalances in these regulators can lead to conditions such as post-traumatic stress disorder (PTSD) or chronic fatigue syndrome (CFS). Understanding the role of biological regulators in neurological and hormonal disorders is crucial to better understand how to treat these different disorders effectively.

Ayman Elsayed Mohamed Elsahar
Guest Editor


Keywords

biological regulation; homeostatic agents; hormones; neurotransmitters; metabolic control; signaling pathways


Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.


Sort by Default Latest Most read  
Please wait a minute...
  • Select all
    |
  • Article
    Bingjie Wu, Handan Hu, Lanxiao Liu, Peng Huang
    Journal of Biological Regulators and Homeostatic Agents. 2023, 37(9): 4623-4633. https://doi.org/10.23812/j.biol.regul.homeost.agents.20233709.452
    Download PDF (17) HTML (0)   Knowledge map   Save

    Background: Obsessive-compulsive disorder (OCD) is a chronic, general, and usually disabling disorder. A family-based study has illustrated that the risk of OCD was related to genetics. This meta-analysis aims to assess the association between solute carrier family 1 member 1 polymorphisms (rs301430 and rs301434) and OCD susceptibility.

    Methods: The study comprehensively searched various databases without language restrictions, including the Cochrane Library database, PubMed, Embase, Web of Science, CNKI, CBM, VIP, and WanFang Data. The data were obtained before April 1, 2023, and odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were utilized and pooled in the analysis using Stata 17.0 software. Sensitivity analysis was conducted to analyze the robustness and reliability of the results, and Egger's test was used to examine the publication bias. Trial Sequential Analysis (TSA) was performed by TSA 0.9.5.10 Beta software to assess the required information size.

    Results: Based on the data derived from eight articles with 3932 participants (2147 OCD subjects and 1785 controls), the risk of OCD and its subtypes were observed to be associated with solute carrier family 1 member 1 (SLC1A1) rs301434 polymorphism (overall OCD: G vs. A: OR = 1.19, 95% CI = 1.06–1.34; GG vs. AA: OR = 2.18, 95% CI = 1.36–3.49; GG+GA vs. AA: OR = 1.21, 95% CI = 1.01–1.45; early-onset OCD: G vs. A: OR = 1.19, 95% CI = 1.04–1.37; GG vs. AA: OR = 1.79, 95% CI = 1.03–3.10; late-onset OCD: GG vs. AA: OR = 3.25, 95% CI = 1.36–7.78; GG vs. GA+AA: OR = 3.22, 95% CI = 1.34–7.76; OCD in Asians: G vs. A: OR = 1.20, 95% CI = 1.00–1.44; GG vs. AA: OR = 3.72, 95% CI = 1.61–8.56; GG vs. GA+AA: OR = 3.70, 95% CI = 1.61–8.51). Meanwhile, no association was found between OCD susceptibility and SLC1A1 rs301430 polymorphism.

    Conclusion: This meta-analysis demonstrates that the SLC1A1 rs310434 may be associated with OCD susceptibility, and more studies are needed to corroborate the conclusions.

    Systematic Review Registration: PROSPERO: CRD42023426696.