Special Issues

Homeostasis of Gut Microbiota and Its Metabolites in Mitigation of Metabolic Disease
Editor: Prabhat Upadhyay

Submission Deadline: 31 January 2024 (Status: Open)

Special Issue Editor

Dr. Prabhat Upadhyay      Email   |   Website
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Interests: neurodegeneration; gut microbiota; inflammation; polyphenols; herbal plant; toxicology; short chain fatty acids; diabetes; obesity

Special Issue Information

Dear Colleagues,

Alteration in the gut microbiota increases the pathogenic bacteria contributing to the development of gastrointestinal diseases, cancer, and metabolic disorders, including obesity, type 2 diabetes, non-alcoholic liver disease, cardio-metabolic diseases, malnutrition, etc. Now research is trending toward the gut-brain axis, gut-liver axis, and gut-muscle axis to solve chronic or genetic disease conditions. Over the last five decades, it has been reported that the herbal plant has riches in dietary polyphenols to prevent metabolic disease through anti-inflammatory and antioxidant activities. Now it has been proven that nutritional polyphenols are directly acting in the modulation of gut microbiota and maintain the gut homeostasis condition. The polyphenols reduce the pathogenic bacteria consortium, maintain the small intestine integrity, and increase short-chain fatty acids production against chronic disease conditions. After SARS-CoV-2, the role of herbal plant/polyphenols increased towards maintaining intestinal homeostasis condition against dysbiosis condition and its role as pre and probiotics.

Prabhat Upadhyay
Guest Editor


short-chain fatty acids; neurodegeneration; obesity; diabetes; gut microbiota; inflammation; polyphenols; herbal plant

Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://www.biolifesas.org/journalx_brha/authorLogOn.action by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. Submitted manuscripts should be well formatted in good English.

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  • Systematic Review
    Matteo Conti, Maria Vadalà, Beniamino Palmieri, Sergio Rexhep Tari, Maria Stella Di Carmine, Felice Lorusso, Sergio Alexandre Gehrke, Francesco Inchingolo, Antonio Scarano
    Journal of Biological Regulators and Homeostatic Agents. 2023, 37(7): 3431-3454. https://doi.org/10.23812/j.biol.regul.homeost.agents.20233707.340
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    Background: Outdated scientific literature claimed that bacteria was a cancerogenic agent. These studies were technically disfavored and the hypothesis of the role of bacteria in cancer was almost completely abandoned for many years. The aim of the present study was to investigate the role of microbiome in carcinogenesis and the potential role of engineered bacteria for the treatment of cancer.

    Materials and Methods: The literature review was performed on Pubmed/Medline, EMBASE, Google Scholar database in accordance to the PRISMA Guidelines. The screening, and eligibility session was performed to conduct the data synthesis of the included studies.

    Results: The screening process included a total of 415 papers, while 389 articles were considered for the eligibility session. A total of 334 scientific products were excluded and 55 articles were considered for the descriptive synthesis. Recent reports, however, have produced new results on the role of various microorganisms in tumors. Here, we reviewed the scientific literature on this issue in order to provide an updated organic framework on the topic.

    Conclusions: Although basic research studies investigated and confirmed the role of bacteria in cancer induction, maintenance and resistance to therapy, the more recent literature is oriented to modern diagnostic approaches from the basic scientific knowledge to the clinical practice. The approaches to biological and immunological onco-therapy, by natural or bioengineered bacteria, were also addressed.

  • Article
    Yuan Wang, Weiyi Zhang, Jianan Wang, Caiju He, Xianwu Zhu
    Journal of Biological Regulators and Homeostatic Agents. 2023, 37(6): 2877-2887. https://doi.org/10.23812/j.biol.regul.homeost.agents.20233706.285
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    Background: Known for its myriad health benefits, konjac glucomannan (KGM), a fermentable fiber, has alleviated constipation and enhanced the population of beneficial gut bacteria. The purpose of this study was to investigate the effects of different concentrations of KGM on the intestinal microorganisms of mice.

    Methods: We utilized the Illumina HiSeq high-throughput sequencing platform to scrutinize mouse gut bacteria's 16S ribosomal RNA (rRNA) V3+V4 region, investigating the effects of feeding low, medium and high KGM doses on the intestinal flora. The multi-faceted analysis included species composition, alpha, and beta diversity analysis, Linear discriminant analysis effect size (LEfSe) flora differential analysis, correlation of flora correlation, and predictive functional analysis, offering comprehensive insights into the varying impacts of KGM dosages.

    Results: The investigation revealed intriguing distinctions in gut microbiota between KGM and control groups. A phylum-level breakdown showed that Firmicutes and Bacteroidetes as the primary microflora across all samples. Notably, the high-dose KGM group exhibited an increased abundance of Firmicutes compared to the control group, coupled with a contrasting decrease in Bacteroidetes. Furthermore, Actinobacteria proliferation was markedly enhanced within the high-dose KGM group. Compared with the control group, all KGM dose groups (low, medium and high) displayed a decline in Deferribacteres, Verrucomicrobia and Proteobacteria. Moreover, mice treated with high-dose KGM showed significantly increased gut populations of Coriobacteriales, Eggerthellaceae, Enterorhabdus, Lactobacillales, Lactobacillaceae, Lactobacillus, Lachnospiraceae_NK4A136_group and others. Interestingly, at the genus level, a positive correlation was observed among Staphylococcus, Corynebacterium and Jeotgalicoccus. In the medium-dose KGM group, amino acid metabolism surged noticeably compared to the control group.

    Conclusions: Our study demonstrates that KGM significantly influences gut microbiota composition in mice. Key shifts include the enhancement of Firmicutes and Actinobacteria, decreasing Deferribacteres, Verrucomicrobia and Proteobacteria, and augmented amino acid metabolism. These findings underline KGM's potential as a prebiotic agent.