JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS Vol. 32, no. 4, 891-897 (2018)
Limb-salvage treatment of malignant tumors of the limbs.
G. LI 1, J. LI 1, C.Y. HU 2, L. TIAN 1, C.A. LV 3 and L.J. JIN 2
1 Orthopedic Department, Affiliated Hong Qi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China
2 Anesthesiology Department, Affiliated Hong Qi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China
3 ICU Department, Affiliated HongQi Hospital of Mu Dan Jiang Medical University, Mudanjiang City, China
The aim of this study was to explore the clinical efficacy of limb-salvage therapy for malignant bone tumors of the limbs using two surgical methods. This investigation presents a retrospective study of malignant bone tumors of the limbs in 42 patients. Participants were divided into two groups: group A of 25 patients who were treated with artificial prosthesis replacement, and group B of 17 patients treated with bone inactivation. By collection of clinical data, the survival rate, surgical complications, quality of life, pain relief and postoperative limb function following artificial prosthesis replacement and tumor inactivation were comprehensively evaluated in patients with malignant bone tumors of the limbs. Group A had significantly higher Karnofsky quality of life scores compared to group B after six months (P=0.027). The Enneking scores of limb functions in group A were significantly higher than those of group B (P=0.022). In group A the postoperative limb function score was good and excellent in 92% and in group B in 64.7%. There were significantly more postoperative complications in group B compared with group A (P=0.027), but no significant difference in the recurrence rate in the two group (P=0.976). The study results can provide reference for surgical treatment of the patients with malignant bone tumors.